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Article

DADA2 as a Model of Monogenic Immune Vasculopathy: From Immunopathogenesis to Precision Therapeutics.

Biomolecules - 19 Jul 2026

Peng Hao, Li Chunxia, Mo Chune, Li Bihui, Ou Minglin

Abstract excerpt

Deficiency of adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disorder caused by biallelic loss-of-function mutations in the ADA2 gene (formerly CECR1). First described in 2014, DADA2 has emerged as a paradigm for monogenic vasculitis, bridging the gap between primary immunodeficiencies and systemic vasculitides. The disease is characterized by a remarkably broad clinical spectrum encompassing...

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Source

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Identifiers

PMID: 42509849
DOI: 10.3390/biom16071057
PMCID: PMC13407256

Genes

ADA2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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