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Article

Single-cell profiling of T lymphocytes in deficiency of adenosine deaminase 2.

Journal of leukocyte biology - 1 Feb 2022

Wu Zhijie, Gao Shouguo, Watanabe Naoki, Batchu Sai, Kajigaya Sachiko, Diamond Carrie, Alemu Lemlem, Raffo Diego Quinones, Feng Xingmin, Hoffmann Patrycja, Stone Deborah, Ombrello Amanda, Young Neal S

Abstract excerpt

Deficiency of adenosine deaminase 2 (DADA2) is a monogenic vasculitis syndrome caused by autosomal-recessive loss-of-function mutations in the ADA2 gene (previously known as CECR1). Vasculitis, vasculopathy, and inflammation are dominant clinical features of this disease; the spectrum of manifestations includes immunodeficiency and lymphoproliferation as well as hematologic manifestations. ADA2 is primarily...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34730257
DOI: 10.1002/JLB.5A0621-314R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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