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A phase 2, open-label, single-arm monotherapy trial of Sulfasalazine in patients with PancrEatic AdenocaRcinoma: Statistical analysis plan for the SPEAR study

2025-12-05

Abstract excerpt

<h4>Background</h4> Pancreatic ductal adenocarcinoma (PDAC) is associated with an extremely poor prognosis, with a 5-year survival rate of less than 9% (1). The SPEAR study is a Phase II, single-arm, open-label, signal-seeking trial evaluating the clinical activity of sulfasalazine, a repurposed anti-inflammatory agent, in patients with advanced or metastatic PDAC who have progressed on one prior line of systemic...

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Literature Corpus work
45add20c-b337-5df2-b81a-dd7301d321dd
DOI
10.64898/2025.12.04.25341652
Open publication

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A phase 2, open-label, single-arm monotherapy trial of Sulfasalazine in patients with PancrEatic AdenocaRcinoma: Statistical analysis plan for the SPEAR studyDOI 10.64898/2025.12.04.25341652
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