Article

The unique nested gene <i>ALZAS</i> as a potential source of Aβ-peptides in Alzheimer’s disease

2018-10-09

Abstract excerpt

Amyloid-beta (Aβ) peptides are considered to be the cause of neuronal and synaptic cell death in Alzheimer’s disease (AD) since approximately 100 years. To date, it is assumed that Aβ-peptides arise from the proteolytic cleavage of the amyloid precursor protein (APP). However, within the APP gene, a nested gene called ALZheimer ASsociated ( ALZAS ) exists, which includes the entire Aβ 42 -sequence and thus may...

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Literature Corpus work: 459c6e34-f9ed-5ef2-8052-1ca6c7235cba
DOI: 10.1101/438630

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