Article

Off-target prediction of SGLT2 inhibitors: an integrative bioinformatics approach to uncover structural mechanisms

2025-01-22

Abstract excerpt

Gliflozin is known to inhibit sodium glucose transporter 2 (SGLT2) inhibitors (SGLT2i). They have been approved for the treatments of diabetes mellitus, cardiovascular diseases, and chronic kidney disease in recent years. However, the mechanisms for the multifunction remain unclear. We here propose a hypothesis of other protein targets for gliflozins. Additionally, the multistage of the protein, the specificity of...

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Literature Corpus work: 45773401-d4ee-5f72-b7e4-8e55a66d712b
DOI: 10.1101/2025.01.20.633821

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