Article

<i>INTS6</i> loss of function disrupts transcriptional regulation in mild intellectual disability

2026-07-17

Abstract excerpt

Pathogenic variants in genes involved in transcriptional regulation and RNA processing have emerged as points of functional convergence in neurodevelopmental disorders (NDDs), but their specific disease mechanisms remain unknown. By screening 1,562 Finnish extended families from the Northern Finland Intellectual Disability cohort affected by cognitive impairment, we discovered a family with six affected members ca...

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Literature Corpus work: 454884dd-83ca-5a5c-bde5-8c7d41d9bcff
DOI: 10.64898/2026.07.17.737701

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