Back to search

Article

Responsive Hydrogel Delivery of DFO-Programmed Apoptotic Bodies Drives Redox-Immuno-Angiogenic Remodeling in Diabetic Wounds

2026-05-11

Abstract excerpt

<title>Abstract</title> <p> Mesenchymal stem cell (MSC)-derived exosomes show clear potential in cell-free regenerative medicine. However, their clinical translation is limited by low production yields and inconsistent therapeutic efficacy. To address this, we actively programmed stem cell apoptosis to generate high-yield, functional extracellular vesicles. By using deferoxamine (DFO) to stabilize HIF-1α prior t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
452cad51-1866-553c-a058-d5a3060917ec
DOI
10.21203/rs.3.rs-9522213/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Responsive Hydrogel Delivery of DFO-Programmed Apoptotic Bodies Drives Redox-Immuno-Angiogenic Remodeling in Diabetic WoundsDOI 10.21203/rs.3.rs-9522213/v1
Repairing the retinal ischemic microenvironment with an engineered exosome-loaded dehydroepiandrosterone peptide hydrogelSemantic proximity
Unraveling the Regenerative Proteomic Signature of <i>Helix aspersa</i> ’s Slime in Human Dermal Fibroblasts by Data-driven Proteomics ApproachSemantic proximity
Lipoaspirate-derived secretome activates NRF2 to restore redox homeostasis and attenuate pathological scar formationSemantic proximity
Sustained ROS Scavenging and Pericellular Oxygenation by Lignin Composites Rescue HIF-1α and VEGF Levels to Improve Diabetic Wound Neovascularization and HealingSemantic proximity
iPSC-derived exosomes promote diabetic wound healing by attenuating inflammatory responsesSemantic proximity
Mechanistic insights into adipose-derived stem cells and exosomes in ischemia-reperfusion injury repair: from shared pathways to organ-specific therapeuticsSemantic proximity
Comparative effects of hypoxia and serum deprivation on the morphological, structural, chemical, biological and functional characteristics of exosomes from adipose-derived mesenchymal stem cellsSemantic proximity
Multifunctional Hydrogel with Mild Photothermal Properties Enhances Diabetic Wound Repair by Targeting MRSA Energy MetabolismSemantic proximity
Functional high capacity exosome-encapsulating bioinspired hydrogel promotes microvascular bed expansion in diabetic miceSemantic proximity
Tower-shaped Super-adhesive Microneedles Loaded with Vitamin A-Containing Bletilla striata Vesicles: Temporally Regulated Inflammation Resolution and ECM Remodeling for Scarless Wound HealingSemantic proximity
Apoptosis Triggering in Breast Cancer Cells with Co-delivery of Melatonin and Doxorubicin Loaded into Human Adipose Mesenchymal Stem Cell Derived ExosomesSemantic proximity
Exosomes derived from fibroblasts enhance skin wound angiogenesis by regulating HIF-1α/VEGF/VEGFR pathwaySemantic proximity
Select a neighboring publication to make it the new centre.