Article

Rapid Detection of AAV8 Binding Antibodies in Gene Therapy Candidates: Development of a Point-of-Care Approach

2025-04-17

Abstract excerpt

<title>Abstract</title> <p>Preexisting anti-AAV antibodies pose a significant challenge to the success of Adeno-associated Virus (AAV) mediated gene therapies, as they can diminish therapeutic effectiveness, restrict patient eligibility for treatment, and cause serious health issues during treatment. This study introduces the first point-of-care (POC) test for the rapid, quantitative detection of AAV8 binding ant...

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Literature Corpus work: 44a39e50-1248-54d2-bd6c-f06c6c9141d2
DOI: 10.21203/rs.3.rs-6297887/v1

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