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Rapid AAV-Neutralizing Antibody Determination with a Cell-Binding Assay

29 Nov 2018

Abstract excerpt

Recombinant adeno-associated virus (rAAV) has been developed as a successful vector for both basic research and human gene therapy. However, neutralizing antibodies (NAbs) against AAV capsids can abolish AAV infectivity on target cells, reducing the transduction efficacy. Absence of AAV NAb has become a prerequisite qualification for patients enrolled in gene therapy trials. Nevertheless, accurate assessment of...

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PMID: 30623003
DOI: 10.1016/j.omtm.2018.11.007

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