Article

Hemophilia B: Analysis of Mutations in the F9 Gene and Perspectives for the Development of Gene Therapy (A Review)

2025-06-25

Abstract excerpt

Abstract Hemophilia B is a severe X-linked recessive disorder caused by mutations in the F9 gene, which encodes blood coagulation factor IX (FIX). This review article examines the main types of mutations and their impact on the structure and function of FIX, as well as the correlation between genetic defects and the clinical manifestations of the disease. The existing approaches to replacement therapy, their effic...

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Literature Corpus work: 449b04b7-aa27-5d5d-a47d-a4442baaf312
DOI: 10.1134/s1990519x25600024

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