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Article

The Molecular Basis of FIX Deficiency in Hemophilia B.

International journal of molecular sciences - 2 Mar 2022

Shen Guomin, Gao Meng, Cao Qing, Li Weikai

Abstract excerpt

Coagulation factor IX (FIX) is a vitamin K dependent protein and its deficiency causes hemophilia B, an X-linked recessive bleeding disorder. More than 1000 mutations in the F9 gene have been identified in hemophilia B patients. Here, we systematically summarize the structural and functional characteristics of FIX and the pathogenic mechanisms of the mutations that have been identified to date. The mechanisms of...

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Identifiers

PMID: 35269902
DOI: 10.3390/ijms23052762
PMCID: PMC8911121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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