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Haemophilia B: From Molecular Diagnosis to Gene Therapy

25 Jan 2003

Abstract excerpt

Thanks to its typical expression, haemophilia can be identified in writings from the second century AD. Haemophilia B, an X-linked recessive bleeding disorder due to factor IX (FIX) deficiency, has an incidence of about 1:30,000 live male births. The factor 9 (F9) gene was mapped in 1984 on Xq27.1. Haemophilia is diagnosed from prothrombin time, activated partial thromboplastin time, and FIX levels. Carrier...

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Identifiers

PMID: 12747585
DOI: 10.1515/cclm.2003.067

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