Article

Calpain DEK1 acts as a developmental switch gatekeeping cell fate transitions

2021-08-25

Abstract excerpt

<h4>Summary</h4> Calpains are cysteine proteases that control cell fate transitions. Although calpains are viewed as modulatory proteases displaying severe, pleiotropic phenotypes in eukaryotes, human calpain targets are also directed to the N-end rule degradatory pathway. Several of these destabilized targets are transcription factors, hinting at a gene regulatory role. Here, we analyze the gene regulatory netwo...

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Literature Corpus work: 4493dc2c-05b7-5ecb-b68a-543390edfae5
DOI: 10.1101/2021.08.25.457637

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