Article

Preclinical models to study the biology and therapy of ovarian cancer

2019-01-01

Abstract excerpt

Ovarian cancer (OC) is one of the most common gynaecological malignancies and a cause of mortality among western women. Standard-of-care treatment consists of platinum/taxane-based chemotherapy, but 5-years survival rate remains low. Germline and somatic mutations in <i>BRCA</i> are present in half of the high grade serous (HGS) ovarian cancer. Olaparib, a PARP inhibitor affecting DNA damage repair pathway, has be...

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Literature Corpus work: cbb621fc-0ab5-5963-8dea-455c9af912ac
DOI: 10.21954/ou.ro.0000e718

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