Article

Prenatal Prediction of Risk of the Fetal Hydantoin Syndrome

1990-10-01

Abstract excerpt

Studies of congenital abnormalities in mothers treated for epilepsy have implicated trimethadione, phenytoin. valproic acid and carbamazepine as potential teratogens. The teratogenicity of drugs such as phenytoin is suspected to be mediated not by the parent compound but by toxic intermediate metabolites. Oxidative intermediates (epoxides) eliminated in a reaction catalyzed by epoxide hydrolase are believed to be...

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Literature Corpus work: 43f74c98-a1f8-53e3-84d5-5da6f98e3a2b
DOI: 10.1097/00132582-199010000-00007

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