Article

Sclerostin directly stimulates osteocyte synthesis of fibroblast growth factor-23

2020-10-29

Abstract excerpt

Osteocyte produced fibroblast growth factor 23 (FGF23) is the key regulator of serum phosphate (Pi) homeostasis. The interplay between parathyroid hormone (PTH), FGF23 and other proteins that regulate FGF23 production and serum Pi levels is complex and incompletely characterised. Evidence suggests that the protein product of the SOST gene, sclerostin (SCL), also a PTH target and also produced by osteocytes, plays...

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Literature Corpus work: 4363f4f0-6385-5e5a-af0b-8a75a4bdf9f0
DOI: 10.1101/2020.10.29.360024

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