Article

Three phylogenetic metrics are compatible with natural evolution of the earliest SARS-CoV-2 sequence

2026-07-14

Abstract excerpt

Comparative analyses of coronavirus sequences can unravel important aspects of their complex evolution. Here we develop a method to infer past recombination breakpoints based on minimizing homoplasies count. We test it on three outbreak viruses (SARS-CoV-1, MERS-CoV, and SARS-CoV-2) and various chimeric coronaviruses as positive controls. We identify genomic regions evolving under distinct selective pressures. We...

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Literature Corpus work: 4344677f-3d8a-5b43-aa1b-8b51c8a5a935
DOI: 10.64898/2026.07.08.737272

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