Identification of Phosphotyrosine-Mutant Desmin in Human Pancreatic Cancer

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC), a deadly cancer with a 5-year survival rate of ∼12%, is characterized by frequently mutated KRAS, early metastasis, and extensive desmoplasia. The latter, a formation of dense fibrotic tissue generated by pancreatic stellar cells (PSC) and tumor cells, makes up to 80% of the tumor mass and leads to treatment failure. To search for novel protein biomarkers for actionable tyr...

Topics

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• Angiogenesis and VEGF in Cancer
• ATP Synthase and ATPases Research
• Autophagy in Disease and Therapy
• Cancer Cells and Metastasis
• Cancer-related molecular mechanisms research
• Pancreatic and Hepatic Oncology Research
• Pancreatitis Pathology and Treatment
• Sphingolipid Metabolism and Signaling

Identifiers and source

Literature Corpus work

41ff7619-c54b-56ca-aca7-c9a29a27dcc3

DOI

10.1101/2024.10.14.618246