Back to search

Article

An Integrated Multi-omics Mendelian Randomization Identifies Predictive Transcription Gene Signature of Liver Fibrosis

2024-06-13

Abstract excerpt

<title>Abstract</title> <p>Background Liver fibrosis is a critical deteriorating onset stage in NASH (Nonalcoholic steatohepatitis) progression towards cirrhosis and even liver cancer. Currently, there is still a lack of non-invasive diagnostic markers for hepatic fibrosis. We conduct multiple public databases associated with Pathway, Network and Mendelian randomization (MR) analysis to identify transcribed gene...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
41b24889-c38c-55ec-baea-c8f36013db59
DOI
10.21203/rs.3.rs-4395597/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
An Integrated Multi-omics Mendelian Randomization Identifies Predictive Transcription Gene Signature of Liver FibrosisDOI 10.21203/rs.3.rs-4395597/v1
Functional investigation and two-sample Mendelian randomization study of non-alcoholic fatty liver disease hub genes obtained by WGCNASemantic proximity
Identification of novel targets associated with cholesterol metabolism in nonalcoholic fatty liver disease: a comprehensive study using Mendelian randomization combined with transcriptome analysisSemantic proximity
Integration of transcriptomic analysis and multiple machine learning approaches identifies NAFLD progression-specific hub genes to reveal distinct genomic patterns and actionable targetsSemantic proximity
Identification of Fatty acid metabolism-Related Genes in the Progression from Non-Alcoholic Fatty Liver to Nonalcoholic fatty liver diseaseSemantic proximity
Unveiling Promising Drug Targets for NAFLD through Mendelian RandomizationSemantic proximity
Integrative multi-omics and multi-trait analysis prioritizes regulatory mechanisms and genes for metabolic dysfunction-associated steatotic liver diseaseSemantic proximity
Non-alcoholic fatty liver disease and heart failure: A comprehensive bioinformatics and Mendelian randomization analysis.Semantic proximity
An novel effective and safe model for the diagnosis of nonalcoholic fatty liver disease in China: gene excavations, clinical validations, and mechanism elucidationSemantic proximity
Deciphering the genetic links between NAFLD and co-occurring conditions using a liver gene regulatory networkSemantic proximity
Identification of key target genes and pathway analysis in nonalcoholic fatty liver disease via integrated bioinformatics analysisSemantic proximity
A network-based approach reveals the dysregulated transcriptional regulation in non-alcohol fatty liver diseaseSemantic proximity
Association of circulating inflammatory proteins with Nonalcoholic Fatty Liver Diseas: a bidirectional Mendelian randomization studySemantic proximity
Select a neighboring publication to make it the new centre.