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Non-alcoholic fatty liver disease and heart failure: A comprehensive bioinformatics and Mendelian randomization analysis.

ESC heart failure - 1 Dec 2024

Zhang Yayun, Feng Lu, Guan Xin, Zhu Zixiong, He Yubin, Li Xuewen

Abstract excerpt

AIMS: Heart failure (HF) and non-alcoholic fatty liver disease (NAFLD) are significant global health issues with a complex interrelationship. This study investigates their shared biomarkers and causal relationships using bioinformatics and Mendelian randomization (MR) approaches. METHODS: We analysed NAFLD and HF datasets from the Gene Expression Omnibus (GEO). The GSE126848 dataset included 57 liver biopsy...

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Computational Biology
Gene Expression Profiling
Genome-Wide Association Study
Heart Failure
Liver Disease Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Non-alcoholic Fatty Liver Disease

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39143741
DOI: 10.1002/ehf2.15019
PMCID: PMC11631243

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