Article

Insulin/IGF-1 signaling modulation in prefrontal cortex is linked to antisuicidal effects in MDD

2025-06-24

Abstract excerpt

<title>Abstract</title> <p>Suicide is a major cause of death worldwide, yet pharmacological options for alleviating suicidality remain limited. Clozapine and ketamine are among the few small molecules with well-documented anti-suicidal effects, direct evidence linking their molecular activity to the genetics of suicide has been scarce. In this study, we conducted a transcriptome-wide association analysis of suici...

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Literature Corpus work: 4133a28b-0121-5995-afa6-61b422f0da5b
DOI: 10.21203/rs.3.rs-5806920/v1

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