Article

Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrate Novel Roles for MMP-13 and ADAMTS-4 in C-Terminal Processing of SLRPs

2018-12-24

Abstract excerpt

Cartilage regeneration requires a balance of anabolic and catabolic processes. This study examined the susceptibility of fibromodulin (FMOD) and lumican (LUM) to degradation by MMP-13, ADAMTS-4 and ADAMTS-5, the three major degradative proteinases in articular cartilage in osteoarthritis (OA). Immunolocalisation of FMOD and LUM in foot sections of developmental cartilages demonstrated prominent localisations in me...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 412fb6f1-2bf4-5343-ba80-92673337a345
DOI: 10.20944/preprints201812.0274.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrate Novel Roles for MMP-13 and ADAMTS-4 in C-Terminal Processing of SLRPsDOI 10.20944/preprints201812.0274.v1Read

The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossificationSemantic proximity Read

The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) familySemantic proximity Read

Protein and transcriptome signatures of cartilage ageing and diseaseSemantic proximity Read

Transcriptomics of Wild‐Type Mice and Mice Lacking ADAMTS‐5 Activity Identifies Genes Involved in Osteoarthritis Initiation and Cartilage DestructionSemantic proximity Read

ADAMTS-18: a metalloproteinase with multiple functions.Semantic proximity Read

Extracellular matrix and pathogenic mechanisms in osteoarthritis.Semantic proximity Read

Degradome expression profiling in human articular cartilageSemantic proximity Read

A Tale of Two Joints: The Role of Matrix Metalloproteases in Cartilage BiologySemantic proximity Read

The role of ADAMTSs in arthritisSemantic proximity Read

ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis.Semantic proximity Read

Matrix metalloproteinases: role in skeletal development and growth plate disordersSemantic proximity Read

Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilageSemantic proximity Read