Article

Peptides Rapidly Transport Antibiotic Across the Intact Tympanic Membrane to Treat a Middle Ear Infection

2023-08-03

Abstract excerpt

The tympanic membrane (TM) forms an impermeable barrier to medical therapies for middle ear (ME) diseases like otitis media. By screening a phage-displayed peptide library, we have previously discovered rare peptides that mediate active transport of cargo across the intact membrane of animals and humans. Since the M13 filamentous bacteriophage on which the peptides are expressed are large (nearly 1 µm in length),...

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Literature Corpus work: 403c7087-21e7-55bf-9644-ba008d334416
DOI: 10.21203/rs.3.rs-3168421/v1

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