Article

SNHG12 Regulated by KMT2B Participates in the Pathogenesis of Renal Cell Carcinoma via E2F1/CEP55

2022-01-04

Abstract excerpt

<title>Abstract</title> <p><bold>Objective:</bold> This study is to investigate the regulation of long non-coding RNA (lncRNA) SNHG12 promoter methylation modification by KMT2B and the mechanism of SNHG12 in the development of renal cell carcinoma (RCC) involving E2F1/CEP55 axis.<bold>Methods:</bold> TCGA and GEO databases were used to predict the involvement of SNHG12 in RCC. Knockdown of SNHG12/E2F1/CEP55 was p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 403159af-0f67-5bb5-9b0f-3c9ea61a7387
DOI: 10.21203/rs.3.rs-1103258/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SNHG12 Regulated by KMT2B Participates in the Pathogenesis of Renal Cell Carcinoma via E2F1/CEP55DOI 10.21203/rs.3.rs-1103258/v1Read

KMT2B promotes the growth of renal cell carcinoma via upregulation of SNHG12 expression and promotion of CEP55 transcriptionSemantic proximity Read

Prognostic and clinical significance of long non-coding RNA SNHG12 expression in various cancersSemantic proximity Read

Identification of the Role of GLS2 in the Development and Progression of Clear Cell Renal Cell Carcinoma.Semantic proximity Read

SNP-mediated lncRNA-ENTPD3-AS1 upregulation suppresses renal cell carcinoma via miR-155/HIF-1α signaling.Semantic proximity Read

LncRNA SNHG17 Promotes Tumor Progression and Predicts Poor Survival in Human Renal Cell Carcinoma via Sponging miR-328-3pSemantic proximity Read

Excavate the role of E2F family in the prognosis, drug sensitivity analyses, and Immune cell infiltration of KIRC (Kidney Clear Cell Carcinoma)Semantic proximity Read

GALNT14 expression in renal clear cell carcinoma and its effect on prognosisSemantic proximity Read

Long noncoding RNA SNHG12 promotes tumour progression and sunitinib resistance by upregulating CDCA3 in renal cell carcinomaSemantic proximity Read

Single-cell RNA-sequencing analysis reveals MYH9 promotes renal cell carcinoma development and sunitinib resistance via AKT signaling pathwaySemantic proximity Read

METTL13 Inhibits Progression of Clear Cell Renal Cell Carcinoma with Repression on PI3K/AKT/mTOR/HIF-1α Pathway and c-Myc ExpressionSemantic proximity Read

ZNF582 overexpression restrains the progression of clear cell renal cell carcinoma by enhancing the binding of TJP2 and ERK2 and inhibiting ERK2 phosphorylationSemantic proximity Read

HDAC8 Enhances the Function of HIF‐2α by Deacetylating ETS1 to Decrease the Sensitivity of TKIs in ccRCCSemantic proximity Read