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Analysis of 20 Independently Performed Assays to Measure Homologous Recombination Deficiency (HRD) in Ovarian Cancer: Findings From the Friends' HRD Harmonization Project

2024-11-01

Abstract excerpt

PURPOSE Homologous recombination deficiency (HRD) assays measure DNA damage repair dysfunction to identify patients with high-grade serous ovarian cancer (HGSOC) who may benefit from poly ADP-ribose polymerase inhibitors (PARPis). Numerous assays are available, but only two have undergone prospective clinical validation. Assay variability can affect patient and provider treatment choices; however, the level of ass...

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Literature Corpus work
3f81f2d0-5da4-5177-b7a6-494ff671a6d0
DOI
10.1200/oa-24-00042
Open publication

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Analysis of 20 Independently Performed Assays to Measure Homologous Recombination Deficiency (HRD) in Ovarian Cancer: Findings From the Friends' HRD Harmonization ProjectDOI 10.1200/oa-24-00042
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