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In-house homologous recombination deficiency testing in ovarian cancer: a multi-institutional Italian pilot study

18 Apr 2023

Abstract excerpt

AIMS: Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPIs) represent a standard of care for the clinical management of high-grade serous ovarian cancer (HGSOC). The recognition of homologous recombination deficiency (HRD) has emerged as a predictive biomarker of response for first-line PARPIs treatment in patients with HGOSC. On the other hand, this test is extremely complex and therefore it is often...

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PMID: 37072171
DOI: 10.1136/jcp-2023-208852

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