Article

Single-cell atlas of reproductive endocrine organs reveals transcriptomic responses to type 1 diabetes mellitus in non-human primate

2025-06-25

Abstract excerpt

<title>Abstract</title> <p>Type 1 diabetes mellitus characterized by insulin deficiency and hyperglycemia is associated with female subfertility. However, how hyperglycemia affects the hypothalamic-pituitary-ovarian-uterine axis remains poorly understood. In this study, we performed single-cell transcriptomic profiling of the hypothalamus, pituitary, ovary and uterus during the proliferative phase of the menstrua...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3e79e99b-865a-5f97-8592-64a921c3e442
DOI: 10.21203/rs.3.rs-6903784/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell atlas of reproductive endocrine organs reveals transcriptomic responses to type 1 diabetes mellitus in non-human primateDOI 10.21203/rs.3.rs-6903784/v1Read

Discrete placental gene expression signatures accompany diabetic disease classifications during pregnancySemantic proximity Read

Exploring the Molecular Link Between Diabetes and Erectile Dysfunction Through Single-Cell Transcriptome AnalysisSemantic proximity Read

Single-cell and proteomic profiling unveil aberrant immune phenotypes in gestational diabetes following assisted reproductive technology.Semantic proximity Read

Immune and oxidative stress disorder in ovulation-dysfunction women revealed by single-cell transcriptomeSemantic proximity Read

An integrated multimodal pan-organ atlas of the female reproductive system across the lifespan contextualises gynaecological pathologiesSemantic proximity Read

Transcriptomic Profiling of Human Placenta in Gestational Diabetes Mellitus at the Single-Cell LevelSemantic proximity Read

Global Transcriptional Profiling of Granulosa Cells from Polycystic Ovary Syndrome Patients: Comparative Analyses of Patients with or without History of Ovarian Hyperstimulation Syndrome Reveals Distinct Biomarkers and PathwaysSemantic proximity Read

Exploring Sex Differences in Type 2 Diabetes via a Male-Dominant Beta-Cell Cluster from Single-Cell Pancreatic Sequencing of Public DatasetsSemantic proximity Read

Placental whole transcriptome expression profile in patients with early-onset, late-onset preeclampsia and gestational diabetes mellitusSemantic proximity Read

A Systems-Level Transcriptomic Analysis of Polycystic Ovary Syndrome as a Mitochondrial-Immunometabolic DisorderSemantic proximity Read

Unravelling the molecular landscape of polycystic ovary syndrome (PCOS) and role of inflammation through transcriptomics analysis of human ovarian granulosa cellsSemantic proximity Read