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Article

Single-cell and proteomic profiling unveil aberrant immune phenotypes in gestational diabetes following assisted reproductive technology.

Communications biology - 29 Jan 2026

Zhu Hui, Cai Jie, Xu Qinyan, Xu Liqi, He Da, Chen Xiang, Chen Tao, Wang Penghao, Li Yuqiong, Ye Wen, Li Bingqi, Huang Jinghan, Guo Doudou, Yu Mengwen, Wu Yiying, Ji Lindan, Tang Nelson L S, Xu Jin

Abstract excerpt

Pregnant women undergoing assisted reproductive technology (ART) have an increased risk of gestational diabetes mellitus (GDM), potentially linked to altered immune regulation, but the underlying circulating immune features remain unclear. Here we show an integrated single-cell transcriptomic, immune receptor repertoire, and plasma proteomic analysis of peripheral blood from 32 women with GDM and 31 normal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41611973
DOI: 10.1038/s42003-026-09615-w
PMCID: PMC12957526

Genes

CD6
CXCL5
FOS
JUN
KLF6
MMP10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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