Article

Characterizing the relationship between the chemical structures of drugs and their activities on primary cultures of pediatric solid tumors

2020-11-02

Abstract excerpt

Better drugs are required to manage pediatric cancers. A high-throughput screen of drugs in primary cultures derived from orthotopic patient-derived xenografts (O-PDX) of pediatric solid tumours has been recently published. Here we analyzed these data sets to find out whether it is possible to leverage them for identifying new drug leads in a phenotypic manner. We found that drugs bearing a higher number of hetero...

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Literature Corpus work: 3e4b2602-967b-5776-a43b-432f5a042cdd
DOI: 10.1101/2020.10.31.363218

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