Article

T1w/T2w ratio suggests reduced intracortical myelin content in youth with RASopathies

2025-09-18

Abstract excerpt

<h4>Background</h4> Myelin may represent a modifiable treatment target in neurodevelopmental disorders, however, a reliable tool for in vivo assessment of myelin alterations in clinical settings is needed. Prior work shows commonly acquired T1-weighted (T1w) and T2-weighted (T2w) scans can be transformed into ratio maps and subsequently provide a reasonable estimate of cortical myelin content. We investigated T1...

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Literature Corpus work: 3dfa11c7-e3a3-5f39-aaea-55aac1e20938
DOI: 10.1101/2025.09.16.25335916

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