Article

Integration of machine learning and pan-genomics expands the biosynthetic landscape of RiPP natural products

2020-05-19

Abstract excerpt

Most clinical drugs are based on microbial natural products, with compound classes including polyketides (PKS), non-ribosomal peptides (NRPS), fluoroquinones and ribosomally synthesized and post-translationally modified peptides (RiPPs). While variants of biosynthetic gene clusters (BGCs) for known classes of natural products are easy to identify in genome sequences, BGCs for new compound classes escape attention....

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Literature Corpus work: 3de51cd7-521d-5183-9556-78ca46507987
DOI: 10.1101/2020.05.19.104752

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