Article

Increased neurovirulence of omicron BA.5 over BA.1 in human brain organoids and K18-hACE2 mice

2023-03-31

Abstract excerpt

<title>Abstract</title><p>The reduced pathogenicity of the omicron BA.1 sub-lineage compared to earlier variants is well described, although whether such attenuation is retained for later variants like BA.5 remains controversial. We show that a BA.5 isolate was significantly more pathogenic in K18-hACE2 mice than a BA.1 isolate, with BA.5 infections showing increased neuroinvasiveness, resulting in brain infection...

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Literature Corpus work: 1bc3dc57-58e7-519e-be92-1755bfca5a01
DOI: 10.21203/rs.3.rs-2702556/v1

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