Article

Long-term daily light exposure boosts photoreceptor maturation in retinal organoids

2025-07-17

Abstract excerpt

Induced pluripotent stem cell-derived retinal organoids (ROs) have become promising personalized models to study inherited retinal diseases (IRDs) and develop new innovative therapies. Although ROs mimic key retinal features and show some light responsiveness, their differentiation and maturation remain limited and lengthy. We hypothesize that standard dark culture conditions limit the expression of genes and prot...

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Literature Corpus work: 3cc4a631-c8fc-589e-a194-7572d5487bc1
DOI: 10.1101/2025.07.17.665292

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