Article

Using reference-free compressed data structures to analyse sequencing reads from thousands of human genomes

2016-06-22

Abstract excerpt

We are rapidly approaching the point where we have sequenced millions of human genomes. There is a pressing need for new data structures to store raw sequencing data and efficient algorithms for population scale analysis. Current reference based data formats do not fully exploit the redundancy in population sequencing nor take advantage of shared genetic variation. In recent years, the Burrows-Wheeler transform (B...

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Literature Corpus work: 3c5d6393-0365-5ee5-8275-1d9d3ed8fe6b
DOI: 10.1101/060186

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