Article

Formation of a hyperdiploid karyotype in childhood acute lymphoblastic leukemia [see comments]

1992-07-01

Abstract excerpt

Abstract Hyperdiploidy with greater than or equal to 50 chromosomes is a frequent and distinct karyotypic pattern in the malignant cells of children with acute lymphoblastic leukemia. To understand better the mechanism of formation of the hyperdiploid karyotype, we studied 15 patients using 20 DNA probes that detect restriction fragment length polymorphisms. We first examined disomic chromosomes for loss of hetero...

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Literature Corpus work: 3c3f5985-291c-5f69-b279-ed2ac3225038
DOI: 10.1182/blood.v80.1.203.203

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