Article

CYP4A11/20-HETE induces oxidative stress and inhibits trophoblast proliferation via the PI3K/AKT signaling pathway during preeclampsia

2023-04-13

Abstract excerpt

<h4>Background: </h4> Placental oxidative stress injury is considered to be a key cause of preeclampsia, but the specific molecules that regulate the balance between oxidant and antioxidant levels remain unclear. 20-Hydroxyeicosatetraenoic acid (20-HETE), an important cytochrome P450 family 4 subfamily A polypeptide 11 (CYP4A11)-dependent eicosanoids, has been proved to increase reactive oxygen species production....

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Literature Corpus work: 3bf320ab-b881-58c2-901e-c031e088b2b5
DOI: 10.21203/rs.3.rs-2772074/v1

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