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Mucoricin binding to β-glucan sites on germinating Mucorales spores disrupts neutrophil swarming to promote pathogenicity

2025-10-29

Abstract excerpt

<h4>Summary</h4> Mucormycosis is an emerging, life-threatening infection caused by Mucorales fungi with incompletely understood immunopathogenesis. We found that unlike other fungal pathogens, Mucorales trigger coordinated neutrophil clustering (swarming) upon swelling of fungal spores. Neutrophil swarms efficiently eliminate germinating Mucorales via ROS production, upon sensing of β-glucan by complement recepto...

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Identifiers and source

Literature Corpus work
3bdec05f-bf55-5711-979e-bd710aa05571
DOI
10.1101/2025.10.28.685056
Open publication

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Mucoricin binding to β-glucan sites on germinating Mucorales spores disrupts neutrophil swarming to promote pathogenicityDOI 10.1101/2025.10.28.685056
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