Back to search

Article

Network pharmacology and experimental validation reveal Salvia miltiorrhiza’s renoprotective mechanisms via PI3K-Akt pathway in diabetic nephropathy

2025-05-15

Abstract excerpt

This study aims to systematically investigate the renoprotective mechanisms of Salvia miltiorrhiza  (SM;丹参) in diabetic nephropathy (DN) through an integrative approach combining network pharmacology, molecular docking, and experimental validation. Bioactive constituents and pharmacological targets of Salvia miltiorrhiza  were identified through systematic bioinformatics mining and protein-protein interaction (P...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6f6e4b25-39e8-5d62-9fb2-113fc4aa4767
DOI
10.22541/au.174731607.76137462/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Network pharmacology and experimental validation reveal Salvia miltiorrhiza’s renoprotective mechanisms via PI3K-Akt pathway in diabetic nephropathyDOI 10.22541/au.174731607.76137462/v1
Exploring the Mechanisms Underlying the Therapeutic Effect of Salvia Miltiorrhiza Against Diabetic Nephropathy Using Network Pharmacology and Molecular DockingSemantic proximity
A network pharmacology approach to explore the mechanism of HuangZhi YiShen Capsule for treatment of diabetic kidney diseaseSemantic proximity
Network pharmacology analysis of ZiShenWan for diabetic nephropathy and experimental verification of its anti-inflammatory mechanismSemantic proximity
Material Basis and Mechanisms of Action of PuRenDan in the Treatment of Type 2 Diabetes Mellitus: An Integrated Network Pharmacology and Molecular Simulation StudySemantic proximity
Network pharmacology and experimental validation of andrographolide’s renoprotective effects on diabetic nephropathy via AGEs-RAGE signaling and mitophagy pathwaysSemantic proximity
Network pharmacology and in vivo experiments reveal the pharmacological effects and molecular mechanisms of Simiao Powder in prevention and treatment for goutSemantic proximity
Medicinal Plants and Phytochemicals used in Diabetic Nephropathy: A Comprehensive ReviewSemantic proximity
A Study on the Mechanism of Milkvetch Root in the treatment of Diabetic Nephropathy based on Network PharmacologySemantic proximity
Mechanism of Astragalus Membranaceus in the Treatment of Diabetic Nephropathy Based on Network PharmacologySemantic proximity
Network Pharmacology Study Reveals the Mechanism of Astragali Radix in Treatment of Diabetic NephropathySemantic proximity
Exploring the Molecular Mechanism of Action of rhein for the Treatment of chronic kidney disease, Using Literature review, NetworkPharmacology and Molecular DockingSemantic proximity
Integrating network pharmacology, molecular docking and simulation approaches with machine learning reveals the multi-target pharmacological mechanism of Berberis integerrima against diabetic nephropathySemantic proximity
Select a neighboring publication to make it the new centre.