Article

Cooperative and Independent Functionality of tmRNA and SmpB: A Multifunctional Exploration Beyond Ribosome Rescue

2024-12-09

Abstract excerpt

The trans-translation system, mediated by transfer-messenger RNA (tmRNA, encoded by the ssrA gene) and its partner protein SmpB, helps release ribosomes stalled on defective mRNA and targets incomplete protein products for hydrolysis. Knocking out the ssrA and smpB genes in various pathogens leads to different phenotypic changes, indicating that they have both cooperative and independent functionalities. This stud...

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Literature Corpus work: 3b8a191f-59a0-5e94-8cb3-8a8da4eeb1a7
DOI: 10.20944/preprints202412.0664.v1

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