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Article

Pre-infection antiviral innate immunity contributes to sex differences in SARS-CoV-2 infection

1 Nov 2022

Abstract excerpt

Male sex is a major risk factor for SARS-CoV-2 infection severity. To understand the basis for this sex difference, we studied SARS-CoV-2 infection in a young adult cohort of United States Marine recruits. Among 2,641 male and 244 female unvaccinated and seronegative recruits studied longitudinally, SARS-CoV-2 infections occurred in 1,033 males and 137 females. We identified sex differences in symptoms, viral...

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PMID: 36323307
DOI: 10.1016/j.cels.2022.10.005

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