Article

The Limits of Haplotype-Based Approaches: Exploring the Applicability of the Li and Stephens Haplotype-Copying Model to Ancient Samples

2023-06-24

Abstract excerpt

The Li and Stephens (LS) haplotype-copying model is a seminal framework that represents a target haplotype as an imperfect mosaic of a set of reference haplotypes. Using a hidden Markov model, it can switch from different source haplotypes to model recombinations. This model has been used in several applications in modern populations including phasing and inference of ancestry. However, recent publications have lo...

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Literature Corpus work: 3ade214a-6315-5251-ae31-a36e20369eff
DOI: 10.1101/2023.06.21.545876

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