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EGFR/APOC1/CPT1A Axis: A Novel Pathway in Gastric Cancer Metabolism and Its Potential as a Therapeutic Target

2024-12-24

Abstract excerpt

<title>Abstract</title> <p>Background Gastric cancer (GC) significantly reprograms lipid metabolism for its energy demands, growth, and survival, yet the role of Apolipoprotein C-I (APOC1) in this metabolic reprogramming and its profound implications for GC progression remains unclear. Methods GC cell lines, microarrays and animal models were utilized to examine APOC1 function. Transcriptomic and metabolomic an...

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Literature Corpus work
3a820bfe-72ab-54ce-b6b1-7bd0b158f956
DOI
10.21203/rs.3.rs-5644413/v1
Open publication

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