Article

Paediatric Intestinal Enteroids Derived from Very Early Onset Inflammatory Bowel Disease Reveal Differences in Growth, Morphology, and Barrier Function

2025-11-14

Abstract excerpt

<title>Abstract</title> <p> Paediatric inflammatory bowel disease (IBD) presents more aggressively than adult-onset disease; however, epithelial pathophysiology remains poorly understood due to limited access to patient tissue. Human intestinal enteroids (HIEs) are a powerful model for investigating disease phenotypes and heterogeneity. We characterized duodenal HIEs from two children with Crohn's disease(ED-7...

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Literature Corpus work: 3975094a-d17c-5805-af2c-99a0603ed98d
DOI: 10.21203/rs.3.rs-8034357/v1

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