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Article

Genome-wide investigation highlights global and local pleiotropy linking neurodevelopmental disorders to acquired hearing problems.

Psychological medicine - 28 Jan 2026

Zhang Qishu, Cabrera-Mendoza Brenda, Chen Qianyu, Davtian David, Qiu Dan, He Jun, Polimanti Renato

Abstract excerpt

BACKGROUND: Neurodevelopmental disorders have been associated with hearing problems (HP) later in life, but there is limited information regarding their shared biology. METHODS: We leveraged large-scale genome-wide datasets to estimate genetic correlation (global and local), polygenic overlap, and locus-specific pleiotropy among HP, autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41593863
DOI: 10.1017/S0033291726103201
PMCID: PMC12885347

Genes

HP
CD33

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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