Article

scDock: Streamlining drug discovery targeting cell-cell communication via scRNA-seq analysis and molecular docking

2025-11-21

Abstract excerpt

<h4>Summary</h4> Identifying drugs that target intercellular communication networks represents a promising therapeutic strategy, yet linking single-cell RNA sequencing (scRNA-seq) analysis to structure-based drug screening remains technically challenging and requires substantial bioinformatics expertise. We present scDock, an integrated and user-friendly pipeline that seamlessly connects scRNA-seq data processing...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3954f1e7-eafb-5ce7-a4e7-aac85e8ded0c
DOI: 10.1101/2025.11.20.689638

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

scDock: Streamlining drug discovery targeting cell-cell communication via scRNA-seq analysis and molecular dockingDOI 10.1101/2025.11.20.689638Read

Cell-Hub: a graphical interface for end-to-end single-cell RNA sequencing analysisSemantic proximity Read

DiSiR: a software framework to identify ligand-receptor interactions at subunit level from single-cell RNA-sequencing dataSemantic proximity Read

Comparative analysis of cell-cell communication at single-cell resolutionSemantic proximity Read

MultiNicheNet: a flexible framework for differential cell-cell communication analysis from multi-sample multi-condition single-cell transcriptomics dataSemantic proximity Read

Lignature: A Comprehensive Database of Ligand Signatures to Predict Cell-Cell CommunicationSemantic proximity Read

Metacells untangle large and complex single-cell transcriptome networksSemantic proximity Read

SeuratExtend: Streamlining Single-Cell RNA-Seq Analysis Through an Integrated and Intuitive FrameworkSemantic proximity Read

Addressing multiple facets of ligand-receptor network inference including single-cell proteomicsSemantic proximity Read

collectNET: a web server for integrated inference of cell-cell communication networkSemantic proximity Read

DIscBIO: a user-friendly pipeline for biomarker discovery in single-cell transcriptomicsSemantic proximity Read

SCAPE: An AI-Driven Platform for Comprehensive Single-Cell Data AnalysisSemantic proximity Read

scRICA: An R package for multiple-sample single-cell RNA-seq data integrative comparative analysisSemantic proximity Read