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Genome Sequencing Enhances Precision and Clinical Utility of Pharmacogenetic Data Compared to Arrays.

Journal of clinical pharmacology - 1 Jul 2026

Numanagić Ibrahim, Similuk Morgan, Sissung Tristan M, Hari Ananth, Ford Michael K B, Walkiewicz Magdalena A, Yan Jia, Ghosh Rajarshi, Lack Justin, Cao Wenjia, Baugher Ryan N, Young Todd B, Manolio Teri, Biesecker Leslie G, Hewitt Stephen M, Sahinalp Suleyman Cenk, Holland Steven M, Figg William D

Abstract excerpt

While pharmacogenetic testing has traditionally relied on array-based genotyping platforms, these methods are limited by incomplete variant coverage and inability to detect novel alleles. We hypothesize that the performance of genome sequencing (GS) is superior to that of an array-based genotyping method for gene-drug pairs that are clinically implemented at the NIH Clinical Center. DNA was collected from a...

Topics

Humans
Pharmacogenetics
Pharmacogenomic Testing
Prospective Studies
Female
Whole Genome Sequencing
Genotype
Male
Genotyping Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42405643
DOI: 10.1002/jcph.70235
PMCID: PMC13496236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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