Article

Antibody-Mediated Blockade for Galectin-3 Binding Protein in Tumor Secretome Abrogates PDAC Metastasis

2021-07-09

Abstract excerpt

<title>Abstract</title> <p>Background One of the major challenges in pancreatic ductal adenocarcinoma (PDAC) management is a local or distant metastasis and limited targeted therapeutics to prevent the process. We aimed to identify a druggable target by screening abnormally secreted protein from PDAC and explore its therapeutic intervention. Methods A LC-MS/MS-based proteomics was carried out for TIF (Tumor Int...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 39036fd2-eaeb-5e1b-8f27-1370216fdd87
DOI: 10.21203/rs.3.rs-676413/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antibody-Mediated Blockade for Galectin-3 Binding Protein in Tumor Secretome Abrogates PDAC MetastasisDOI 10.21203/rs.3.rs-676413/v1Read

Detection of incipient pancreatic cancer with novel tumor-specific antibodies in mouse modelsSemantic proximity Read

The Galectin Family as Molecular Targets: Hopes for Defeating Pancreatic CancerSemantic proximity Read

Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling.Semantic proximity Read

The clinical significance of <i>MAGEA3</i> expression in pancreatic cancerSemantic proximity Read

Development of a Novel Anti-CD44 Variant 5 Monoclonal Antibody C<sub>44</sub>Mab-3 for Multiple Applications against Pancreatic CarcinomasSemantic proximity Read

CA19-9 promotes liver metastasis of pancreatic cancer through E-selectin mediated extravasationSemantic proximity Read

Targeting a proteolytic neo-epitope of CUB-domain containing protein 1 in RAS-driven cancerSemantic proximity Read

HER3 as biomarker and therapeutic target in pancreatic cancer: new insights in pertuzumab therapy in preclinical modelsSemantic proximity Read

DPP3 expression promotes cell proliferation and migration in vitro and tumor growth in vivo that associates with poor prognosis of esophageal carcinomaSemantic proximity Read

Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinomaSemantic proximity Read

Detection of pancreatic cancer using antibody microarray‐based serum protein profilingSemantic proximity Read

G<sub>4</sub>Mab-9: An Anti-Glypican-4 Monoclonal Antibody for Multiple ApplicationsSemantic proximity Read