Back to search

Article

Exploring the Role of Natural Compounds in Preventing Alzheimer's Disease Progression: A Multi-Target Interaction Study of Carnosine and Homocarnosine with the Aβ(1-42) peptide using Molecular Docking

2023-02-13

Abstract excerpt

Alzheimer's disease (AD) is a debilitating condition that affects memory and behavior, typically in older individuals. Among the conjectures for AD causes, the so-called metallic hypothesis is still a topic of ongoing research and debate. It suggests that exposure to specific metallic ions like zinc, copper, and iron may contribute to the development of the disease. In this study, we investigate how using molecula...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
384a389e-edda-5b9d-89c1-cdca3bf87e00
DOI
10.21203/rs.3.rs-2566478/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Exploring the Role of Natural Compounds in Preventing Alzheimer's Disease Progression: A Multi-Target Interaction Study of Carnosine and Homocarnosine with the Aβ(1-42) peptide using Molecular DockingDOI 10.21203/rs.3.rs-2566478/v1
Exploring the differences between mouse mAβ(1-42) and human hAβ(1-42) for Alzheimer's disease related properties and neuronal cytotoxicity.Semantic proximity
Acetylcholinesterase Inhibitory Potential of Plant-Based Phenolics in the Treatment of Alzheimer's Disease: An In Silico ApproachSemantic proximity
A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's diseaseSemantic proximity
A Novel multifunctional 5,6-dimethoxy-indanone-chalcone-carbamate hybrids alleviates cognitive decline in Alzheimer’s disease by dual inhibition of acetylcholinesterase and inflammationSemantic proximity
Discovery of novel thiosemicarbazone-acridine targeting butyrylcholinesterase with antioxidant, metal complexing and neuroprotector abilities as potential treatment of Alzheimer's disease: In vitro, in vivo, and in silico studiesSemantic proximity
Amino acids variations in amyloid-beta peptides, mitochondrial dysfunction, and new therapies for Alzheimer's disease.Semantic proximity
Zinc transporters in Alzheimer’s diseaseSemantic proximity
Hopeahainol <scp>A</scp> attenuates memory deficits by targeting β‐amyloid in <scp>APP</scp>/<scp>PS</scp>1 transgenic miceSemantic proximity
Quantification of the binding properties of Cu2+ to the amyloid beta peptide: coordination spheres for human and rat peptides and implication on Cu2+-induced aggregation.Semantic proximity
Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer’s DiseaseSemantic proximity
Identification of dual inhibitors against BACE1 and GSK-3β for the treatment of Alzheimer’s disease: An in silico-based approachSemantic proximity
Reactive oxygen species in Alzheimer's disease : studies of amyloid-beta-copper and apolipoprotein ESemantic proximity
Select a neighboring publication to make it the new centre.