Article

NEK9 ablation rewires docetaxel resistance through induction of ERK-mediated cancer cell pyroptosis

2024-09-14

Abstract excerpt

Docetaxel alone or in combination with other drugs is the most common chemotherapy regimen for several neoplasms including advanced OSCC. Unfortunately, chemoresistance leads to relapse and continued tumor growth. It is therefore important to explore the causative factors for docetaxel resistance. In this study, we performed a CRISPR-based kinome screening that identified Never In Mitosis Gene-A Related Kinase-9 (...

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Literature Corpus work: 36d19635-897e-579d-919b-6f6178c1b73d
DOI: 10.1101/2024.09.10.612209

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