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Article

Limited Generalizability of Epigenetic Clocks and Scores Across Pediatric Tissues and Age Ranges

2025-12-15

Abstract excerpt

Epigenetic clocks and scores have been investigated as potential biomarkers of later-life health outcomes following early-life exposures. In pediatric settings, DNA methylation (DNAm) is often measured in saliva; however, most clocks and scores have been trained in adult blood. Therefore, we assessed the performance, correlation, longitudinal stability, and association with early-life adversity (ELA) for establish...

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Literature Corpus work
36b8d9b9-ea80-530b-8ef2-1c0822c3e0d2
DOI
10.64898/2025.12.11.25340872
Open publication

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Limited Generalizability of Epigenetic Clocks and Scores Across Pediatric Tissues and Age RangesDOI 10.64898/2025.12.11.25340872
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